Active DNA demethylation upstream of rod-photoreceptor fate determination is required for retinal development

TET enzymes remove DNA methylation markers, but th...

TET enzymes remove DNA methylation markers, but the role of this process in retinal development is not clear. This study shows that these enzymes are required for photoreceptor cells to initiate the genetic program to become rods instead of cones, and for mat…

Ismael Hernández-Núñez, Alaina Urman, Xiaodong Zhang, William Jacobs, Christy Hoffmann, Ellen G. Harding, Shiming Chen, Meelad M. Dawlaty, Philip A. Ruzycki, John R. Edwards, Brian S. Clark
Plos.org